Ingredients & Science

“Clinical-Grade Nutrients for Smarter Surgical Recovery”

Proven ingredients for joint healing, strength preservation, and inflammation control—backed by peer-reviewed clinical studies.

  • 1. Essential Amino Acids (EAAs)
    • What they are: The nine amino acids your body can’t make on its own.
    • Why Ovial includes them: They’re the most potent stimulus for muscle protein synthesis, especially leucine.
    • Science: A high-quality randomized controlled trial (RCT) in total knee replacement patients showed perioperative EAA supplementation reduced thigh muscle loss and improved strength—benefits persisted over long-term follow-up.
    • Benefit: EAAs help “lock in” your strength before surgery and contribute to faster functional recovery.
  • 2. Bioactive Collagen Peptides (TENDOFORTE) + Vitamin C
    • What they do: Collagen peptides supply raw material for tendon, ligament, and skin matrix repair. Vitamin C catalyzes cross-linking—critical for durable collagen.
    • Science: TENDOFORTE has been clinically proven to increase RNA expression of collagen, specifically elastin. Additionally, TENDOFORTE produces 1.2-2.4x more Fibroblast proliferative matrix compared to normal collagen supplementation.
    • Benefit: Ovial PRE amplifies your connective tissue healing potential, priming you before surgical stress.
  • 3. Omega-3 Fatty Acids (EPA/DHA)
    • What they do: Inflammation modulator; supports resolution and may preserve joint mobility.
    • Science: Meta-analyses show omega-3s can limit postoperative inflammatory responses without increasing bleeding risk at normal doses. Long-term use improves pain and function in osteoarthritis patients.
    • Benefit: A pro-recovery anti-inflammatory that complements rehab and supports long-term joint health.
  • 4. Creatine Monohydrate
    • Purpose: Replenishes phosphocreatine stores—important for rapid muscle energy during movement.
    • Science: In several studies on immobilization after orthopedic surgery, creatine demonstrated the potential to maintain muscle mass when movement resumes.
    • Benefit: Beneficial for rehab strength bursts; individual response may vary depending on surgery type.
  • 5. Curcumin
    • What is Curcumin: A turmeric-derived polyphenol with antioxidant and anti-inflammatory properties.
    • Science: RCTs in knee osteoarthritis show pain relief comparable to NSAIDs; pilot surgical studies (e.g., joint, dental procedures) suggest it may lower analgesic needs.
    • Benefit: A natural addition to surgical pain management (use as part of a broader multimodal plan and discuss with your provider).
  • 6. Vitamin D (Cholecalciferol)
    • Purpose: Essential for calcium balance, bone mineralization, muscle function, and immune response.
    • Science: Deficiency is linked to worse outcomes and longer hospital stays after total knee arthroplasty. Correcting deficiency improves post-op results.
    • Benefit: A foundational nutrient for bone healing and recovery; ensure pre-op sufficiency.
  • 7. Vitamin C & Antioxidants
    • Why they matter: Vitamin C is essential to collagen formation; antioxidants help buffer oxidative stress from surgery.
    • Science: Perioperative IV vitamin C reduced morphine needs and pain in hip arthroplasty. Daily vitamin C significantly cut the incidence of CRPS in wrist fracture patients.
    • Benefit: A dual role in healing and pain control, making recovery smoother and potentially reducing opioid needs.
  • 8. Additional Micronutrients (Zinc, Magnesium, B Vitamins)
    • Role: Zinc supports wound healing and immune function. Magnesium plays a role in muscle and bone health. B vitamins help energy metabolism.
    • Science: Years of research have demonstrated that these nutrients are essential for cellular recovery and are commonly low in stressed or aging populations. Magnesium glycinate has been clinically demonstrated to improve sleep in several randomized studies.
    • Benefit: Ovial includes a well-rounded micronutrient profile to cover common surgical nutrition gaps. Furthermore, OVIAL POST can improve sleep which can be difficult post-operatively.
  • 9. WHEY PROTEIN ISOLATE
    • What it is: A highly purified, rapidly absorbed form of protein derived from milk, providing essential amino acids with minimal fat, lactose, and digestive burden.
    • Why Ovial includes it: After surgery, protein needs increase while appetite often decreases. Whey protein isolate provides a concentrated, easily digestible source of high-quality protein to help patients meet protein needs during early recovery.
    • Science: Whey protein has been extensively studied in surgical and immobilized populations and is known to effectively stimulate muscle protein synthesis due to its high leucine and essential amino acid content.
    • Benefit: Whey protein isolate helps support muscle maintenance and strength during recovery, particularly when normal eating patterns are disrupted.
  • 10. CALCIUM HMB (β-Hydroxy-β-Methylbutyrate)
    • What it is: A metabolite of the amino acid leucine that plays a role in regulating muscle protein breakdown and preservation, particularly during periods of stress or inactivity.
    • Why Ovial includes it: After surgery, muscle loss is driven not only by reduced use, but also by increased breakdown. Calcium HMB helps support muscle preservation when normal movement and training are limited.
    • Science: Clinical studies in surgical, immobilized, and older adult populations have shown that HMB supplementation can help reduce muscle loss and support strength during periods of catabolic stress, including after orthopedic procedures.
    • Benefit: Calcium HMB helps protect muscle during the early post-operative period, supporting strength retention when patients are most vulnerable to muscle loss.
1. Essential Amino Acids (EAAs)
  • What they are: The nine amino acids your body can’t make on its own.
  • Why Ovial includes them: They’re the most potent stimulus for muscle protein synthesis, especially leucine.
  • Science: A high-quality randomized controlled trial (RCT) in total knee replacement patients showed perioperative EAA supplementation reduced thigh muscle loss and improved strength—benefits persisted over long-term follow-up.
  • Benefit: EAAs help “lock in” your strength before surgery and contribute to faster functional recovery.
2. Bioactive Collagen Peptides (TENDOFORTE) + Vitamin C
  • What they do: Collagen peptides supply raw material for tendon, ligament, and skin matrix repair. Vitamin C catalyzes cross-linking—critical for durable collagen.
  • Science: TENDOFORTE has been clinically proven to increase RNA expression of collagen, specifically elastin. Additionally, TENDOFORTE produces 1.2-2.4x more Fibroblast proliferative matrix compared to normal collagen supplementation.
  • Benefit: Ovial PRE amplifies your connective tissue healing potential, priming you before surgical stress.
3. Omega-3 Fatty Acids (EPA/DHA)
  • What they do: Inflammation modulator; supports resolution and may preserve joint mobility.
  • Science: Meta-analyses show omega-3s can limit postoperative inflammatory responses without increasing bleeding risk at normal doses. Long-term use improves pain and function in osteoarthritis patients.
  • Benefit: A pro-recovery anti-inflammatory that complements rehab and supports long-term joint health.
4. Creatine Monohydrate
  • Purpose: Replenishes phosphocreatine stores—important for rapid muscle energy during movement.
  • Science: In several studies on immobilization after orthopedic surgery, creatine demonstrated the potential to maintain muscle mass when movement resumes.
  • Benefit: Beneficial for rehab strength bursts; individual response may vary depending on surgery type.
7. Vitamin C & Antioxidants
  • Why they matter: Vitamin C is essential to collagen formation; antioxidants help buffer oxidative stress from surgery.
  • Science: Perioperative IV vitamin C reduced morphine needs and pain in hip arthroplasty. Daily vitamin C significantly cut the incidence of CRPS in wrist fracture patients.
  • Benefit: A dual role in healing and pain control, making recovery smoother and potentially reducing opioid needs.
8. Additional Micronutrients (Zinc, Magnesium, B Vitamins)
  • Role: Zinc supports wound healing and immune function. Magnesium plays a role in muscle and bone health. B vitamins help energy metabolism.
  • Science: Years of research have demonstrated that these nutrients are essential for cellular recovery and are commonly low in stressed or aging populations. Magnesium glycinate has been clinically demonstrated to improve sleep in several randomized studies.
  • Benefit: Ovial includes a well-rounded micronutrient profile to cover common surgical nutrition gaps. Furthermore, OVIAL POST can improve sleep which can be difficult post-operatively.
9. WHEY PROTEIN ISOLATE
  • What it is: A highly purified, rapidly absorbed form of protein derived from milk, providing essential amino acids with minimal fat, lactose, and digestive burden.
  • Why Ovial includes it: After surgery, protein needs increase while appetite often decreases. Whey protein isolate provides a concentrated, easily digestible source of high-quality protein to help patients meet protein needs during early recovery.
  • Science: Whey protein has been extensively studied in surgical and immobilized populations and is known to effectively stimulate muscle protein synthesis due to its high leucine and essential amino acid content.
  • Benefit: Whey protein isolate helps support muscle maintenance and strength during recovery, particularly when normal eating patterns are disrupted.
10. CALCIUM HMB (β-Hydroxy-β-Methylbutyrate)
  • What it is: A metabolite of the amino acid leucine that plays a role in regulating muscle protein breakdown and preservation, particularly during periods of stress or inactivity.
  • Why Ovial includes it: After surgery, muscle loss is driven not only by reduced use, but also by increased breakdown. Calcium HMB helps support muscle preservation when normal movement and training are limited.
  • Science: Clinical studies in surgical, immobilized, and older adult populations have shown that HMB supplementation can help reduce muscle loss and support strength during periods of catabolic stress, including after orthopedic procedures.
  • Benefit: Calcium HMB helps protect muscle during the early post-operative period, supporting strength retention when patients are most vulnerable to muscle loss.
  • Formulated by Surgeons

    Designed with surgical recovery in mind.

  • Third-Party Tested

    Verified for quality, purity, and accuracy.

  • Gluten-Free

    No gluten ingredients in the formula.

  • Made in the USA

    Manufactured in a certified U.S. facility.

Formulated by Surgeons

Designed with surgical recovery in mind.

Third-Party Tested

Verified for quality, purity, and accuracy.

Gluten-Free

No gluten ingredients in the formula.

Made in the USA

Manufactured in a certified U.S. facility.

Clinical Evidence

Research and consensus documents supporting early recovery, muscle preservation, and post-surgical nutrition.